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This post explains how to disable mod_security using .htaccess for one domain. You may have problem with mod_security if you are using certain plugins, wordpress, etc.
Go to your public_html directory of the desired domain and in .htaccess file add the following lines.
#vi .htaccess
SecFilterEngine Off
SecFilterScanPOST Off
Thats it. Mod_sec has been disabled now.

